Où > Ici

Electrophysiology

I have been working on intracellular recording techniques. In particular, I invented the Active Electrode Compensation technique, to estimate and subtract the electrode voltage in single-electrode recordings; this was a strongly interdisciplinary project involving theoreticians (in particular Alain Destexhe) and experimentalists (in particular Zuzanna Piwkowska and Thierry Bal). We have been developing, testing and applying the technique in various experimental setups. This work is supported by the ANR grant HR-CORTEX.

I am also editing a book entitled "Handbook of neural activity measurement" (Cambridge University Press, coedited with Alain Destexhe), about modelling neural measurements, and I am currently writing the chapter about intracellular electrophysiology.

Relevant publications:

1. Brette et al (2008). High-resolution intracellular recordings using a real-time computational model of the electrode. Neuron 59(3):379-91.
2. Brette R, Piwkowska Z, Monier C, Gomez J, Frégnac Y, Bal T, Destexhe A (2008). Dynamic clamp with high resistance electrodes in vitro and in vivo. Chapter in Dynamic Clamp, Bal T and Destexhe A (eds).
3. Badel L, Lefort S, Brette R, Petersen CC, Gerstner W, Richardson MJ (2008). Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces. J Neurophysiol 99(2):656-66.
4. Brette, R., Piwkowska, Z., Rudolph, M., Bal, and A. Destexhe (2007). A non-parametric electrode model for intracellular recording. Neurocomputing 70(10-12): 1597-1601 (Conference proceedings, CNS 2006, Edinburgh, UK).

is there!

Book: The Handbook of Neural Activity Measurement